This page is provided for research and educational purposes only and does not provide medical advice, diagnosis, treatment recommendations, dosing instructions, or instructions for human use. Research findings should be interpreted within the population, model, formulation, route, outcomes, and study design reported by each cited source.
Epitalon / Epithalon (10 mg Vial)
Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from pineal gland research for its geroprotective potential[1]. Epitalon activates telomerase to promote telomere elongation, supports healthy melatonin production for improved sleep and circadian rhythm regulation, and has demonstrated lifespan extension in animal models[2][3]. A 12-year human study cited on this page evaluated epithalamine, a pineal-gland peptide preparation, rather than synthetic tetrapeptide Epitalon[4].
Quick Reference
What is Epitalon / Epithalon?
Research overview based on the cited scientific literature.
• Goal: Support telomere maintenance, melatonin regulation, and geroprotective effects over time[2].
• Storage: Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.
Storage Instructions
Proper storage preserves peptide quality.
• Lyophilized: Store at −20 °C (−4 °F) for long-term; refrigerate at 2–8 °C (35.6–46.4 °F) for routine storage; minimize moisture exposure[6].
• Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); use within 2–4 weeks and avoid freeze–thaw[7].
• Allow vials to reach room temperature before opening to reduce condensation uptake.
How is Epitalon / Epithalon studied?
Epitalon’s primary mechanism involves telomerase activation, promoting telomere elongation in cells[2]. In vitro studies demonstrated that Epitalon induced telomerase and lengthened telomeres in human cell cultures, allowing cells to continue dividing beyond the usual Hayflick limit[9]. Epitalon also influences the neuroendocrine system by stimulating nocturnal melatonin release from the pineal gland, thereby normalizing circadian hormone rhythms in aged subjects[3]. Additional reported effects include antioxidant activity, genomic regulatory effects, and immune modulation[1].
What does the research report about Epitalon / Epithalon?
Observations from preclinical and clinical literature.
• Supports telomere maintenance and cellular longevity through telomerase activation[2][9].
• Restores healthy melatonin production and circadian rhythm regulation[3].
• Extended lifespan and reduced tumor incidence observed in animal models[1].
• A 12-year randomized study in elderly patients with coronary disease evaluated epithalamine, described as a pineal-gland peptide preparation, and reported cardiovascular and mortality outcomes[4]. It did not study synthetic tetrapeptide Epitalon, so those results should not be presented as direct Epitalon evidence.
• Generally well tolerated; no serious adverse events reported in long-term studies[5].
• Occasional mild injection-site reactions or transient sleep pattern changes may occur.
Important Note
This content is provided for scientific research and educational purposes only. It does not provide medical advice, diagnosis, treatment, dosing, or administration instructions. The compounds discussed may be investigational and are not presented as approved for human use.
Research FAQs
1 Did the cited 12-year study test synthetic Epitalon?
No. Reference [4] evaluated epithalamine, described as a pineal-gland peptide preparation. Its results should not be presented as direct evidence for synthetic tetrapeptide Epitalon.
2 Why distinguish epithalamine from Epitalon?
Study findings apply to the intervention actually investigated. Sharing a research background does not make a peptide preparation and a synthetic tetrapeptide interchangeable[4].
What are the limitations of the research on Epitalon / Epithalon?
Evidence should be interpreted within the population, experimental model, formulation, route, outcome measures, and study design used in each cited source. Preclinical or early-stage findings do not establish clinical efficacy, safety, or approved human use. Where human evidence is available, results should not be generalized beyond the populations and conditions actually studied.
