This page is provided for research and educational purposes only and does not provide medical advice, diagnosis, treatment recommendations, dosing instructions, or instructions for human use. Research findings should be interpreted within the population, model, formulation, route, outcomes, and study design reported by each cited source.
HMG (75 IU Vial)
Human Menopausal Gonadotropin (HMG) is a purified gonadotropin preparation containing equal amounts of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity[1][2]. In males, HMG is used alongside hCG to stimulate spermatogenesis in cases of hypogonadotropic hypogonadism or infertility[3][4].
Quick Reference
What is HMG (75 IU Vial)?
Research overview based on the cited scientific literature.
• Goal: Stimulate spermatogenesis in males with hypogonadotropic hypogonadism or infertility[3][4].
• Storage: Lyophilized refrigerated; reconstituted solution used promptly or within days when refrigerated.
Storage Instructions
Proper storage maintains HMG stability and potency.
• Lyophilized (unopened): Store at 2–8 °C (35.6–46.4 °F) away from light; stable at controlled room temperature up to 25 °C (77 °F)[9].
• Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); for best potency use promptly (official guidance recommends immediate use with plain diluent)[9].
• With bacteriostatic water, reconstituted solution may be refrigerated and used within a few days.
• Protect from light at all times; discard any unused solution if not used within recommended timeframe.
How is HMG (75 IU Vial) studied?
HMG provides both FSH and LH activity in a 1:1 ratio, derived from purified human menopausal urine[1][2]. In males with hypogonadotropic hypogonadism, FSH stimulation is essential for spermatogenesis (sperm production)[3]. When hCG alone fails to induce adequate sperm production, adding HMG provides the necessary FSH activity to support testicular function and fertility[5][6]. Clinical studies demonstrate that HMG combined with hCG significantly improves sperm parameters including motility, morphology, and concentration, with enhanced pregnancy rates in treated couples[7][12].
What does the research report about HMG (75 IU Vial)?
Observations from clinical fertility literature.
Potential Benefits:
• Stimulates spermatogenesis in men with hypogonadotropic hypogonadism or secondary infertility[3][4].
• Improves sperm motility, morphology, and concentration when combined with hCG therapy[7][12].
• Significantly increases pregnancy rates in couples undergoing fertility treatment[7].
• Supports normal testicular function and hormone production[5][6].
Potential Side Effects:
• Injection site reactions (redness, swelling, mild pain)[8].
• Headache, fatigue, or mood changes (uncommon).
• Gynecomastia (breast tissue development) due to hormonal stimulation.
• Overstimulation effects if dosing is excessive (rare in males with proper monitoring).
• Allergic reactions (rare); discontinue if hypersensitivity occurs.
Research Limitations / Risk Notes
The 3.0 mL injection volume may require splitting into multiple smaller injections or using larger-capacity syringes. Official Menopur guidance typically uses a smaller reconstitution volume and recommends immediate use after reconstitution[8][9]. Clinical response may require at least 12 weeks, while spermatogenesis can take 3–6 months to fully develop[7].
Important Note
This content is provided for scientific research and educational purposes only. It does not provide medical advice, diagnosis, treatment, dosing, or administration instructions. The compounds discussed may be investigational and are not presented as approved for human use.