Vesugen (Lys-Glu-Asp) (20 mg Vial)

Research overview by Biohacking Elite · Last updated October 24, 2026
Research information notice

This page is provided for research and educational purposes only and does not provide medical advice, diagnosis, treatment recommendations, dosing instructions, or instructions for human use. Research findings should be interpreted within the population, model, formulation, route, outcomes, and study design reported by each cited source.

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Vesugen (Lys-Glu-Asp) (20 mg Vial)

RESEARCH & EDUCATIONAL REFERENCE GUIDE

This information is for research and educational use only.

! For research and educational purposes only. Review all research information, limitations and references before interpretation.
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Vesugen (Lys-Glu-Asp) (20 mg Vial)
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Quick Reference

Alternate / Common Names
Lys-Glu-Asp; KED
Classification
Tripeptide bioregulator Lys-Glu-Asp (KED)
Vial / Reference Strength
20 mg
Product / Research Format
Lyophilized peptide

What is Vesugen (Lys-Glu-Asp)?

Research overview based on the cited scientific literature.

Goal: Support vascular endothelial function and cellular renewal over time[2].

Storage: Lyophilized frozen; reconstituted refrigerated; avoid repeated freeze–thaw.

Storage Instructions

Proper storage preserves peptide quality[10].
Lyophilized: Store at −20 °C (−4 °F) in dry, dark conditions; minimize moisture exposure.
Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); prepare aliquots if needed and avoid freeze–thaw.
Allow vials to reach room temperature before opening to reduce condensation uptake.

How is Vesugen (Lys-Glu-Asp) studied?

Vesugen (KED) is a tripeptide derived from amino acids associated with vascular wall proteins[1]. Research indicates it may support vascular endothelial cell proliferation by modulating the expression of Ki-67, a protein closely associated with cell division[2]. The peptide is hypothesized to interact with promoter regions of the Ki-67 gene, potentially influencing epigenetic regulation[3]. Additional studies suggest Vesugen may normalize endothelin-1 expression and increase sirtuin-1 (SIRT-1) expression in vascular endothelial cells[4].

What does the research report about Vesugen (Lys-Glu-Asp)?

Observations from preclinical and cell culture research.
May support vascular endothelial cell proliferation and renewal through Ki-67 gene regulation[2][3].
Research suggests potential neuroprotective properties; oral application improved memory and attention in elderly individuals with functional CNS disorders[5].
May restore synaptic plasticity in in vitro models of Alzheimer’s disease[6].
Generally well tolerated in reported studies; occasional mild injection-site reactions (redness/itch) may occur with subcutaneous administration.

Important Note

This content is provided for scientific research and educational purposes only. It does not provide medical advice, diagnosis, treatment, dosing, or administration instructions. The compounds discussed may be investigational and are not presented as approved for human use.

What are the limitations of the research on Vesugen (Lys-Glu-Asp)?

Evidence should be interpreted within the population, experimental model, formulation, route, outcome measures, and study design used in each cited source. Preclinical or early-stage findings do not establish clinical efficacy, safety, or approved human use. Where human evidence is available, results should not be generalized beyond the populations and conditions actually studied.

References

[1]
Bull Exp Biol Med (2016)— Short Peptides Regulate Gene Expression (Khavinson et al.)
Bull Exp Biol Med (2016)
[2]
Adv Gerontol (2014)— Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging
Adv Gerontol (2014)
[3]
Molecules (2021)— Peptide Regulation of Gene Expression: A Systematic Review (MDPI)
Molecules (2021)
[4]
Adv Gerontol (2016)— Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis
Adv Gerontol (2016)
[5]
Bull Exp Biol Med (2021)— Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer’s Disease
Bull Exp Biol Med (2021)
[6]
Bull Exp Biol Med (2017)— Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease
Bull Exp Biol Med (2017)
[7]
DailyMed— Bacteriostatic Water injection, solution (FDA labeling)
DailyMed
[8]
PMC (2024)— Practical advice in the development of a lyophilized protein drug product
PMC (2024)
[9]
MedlinePlus— Subcutaneous (SQ) injections: technique and site guidance
MedlinePlus
[10]
NCBI Bookshelf— Best practices for injection (WHO guidelines)
NCBI Bookshelf

Additional Research and Background

[1]
Int J Mol Sci (2022)— Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease
Int J Mol Sci (2022)
[2]
Pharmaceuticals (2021)— Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer’s Disease
Pharmaceuticals (2021)
[3]
Biogerontology (2010)— Peptide bioregulation of aging: Results and prospects (Anisimov & Khavinson)
Biogerontology (2010)
[4]
Stem Cell Rev Rep (2020)— Peptide Regulation of Cell Differentiation
Stem Cell Rev Rep (2020)
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